![]() However, proof of concept is often missing from such research reports, with most data focusing mainly on the formulation aspects only. Nanoformulation technology has emerged formidable in this regard and a survey of the literature shows that this is the new frontier in the quest for achieving clinically relevant plasma concentrations from Class III and IV drugs when administered orally. In order to elicit therapeutic plasma concentrations, novel drug delivery technologies have been proposed. These drugs register poor systemic bioavailability when administered orally using conventional dosage forms such as tablets or capsules. Review articles critically analyzing the success and failures of various formulation approachesĬlass III and IV drugs of the biopharmaceutical classification system represent drugs with poor solubility and/or epithelial permeability, thus representing the bulk of drugs under current development by formulation scientists.Ĝlinical studies on Class III and IV drugs in nanoformulation intended for oral delivery.Key physiological and anatomical parameters that affect delivery of Class III/IV drugs in nanoformulations.Pharmacokinetic and pharmacodynamic studies via cell or animal models involving Class III / IV drugs in pure form or nanoformulated.Physicochemical characterization pointing key parameters that need to be considered in developing viable nanoformulations intended for oral delivery.Key processing and formulation parameters that need to be considered in the nanoencapsulation of class III and IV drugs intended for oral delivery.For this Research Topic, we welcome Original Research and Reviews on themes including, but not limited to: In the trajectory of realizing the application of nanoformulation in improving the bioavailability of Class III and IV drugs, it is about time to assess how far we have gone. Class III and IV drugs of the biopharmaceutical classification system represent drugs with poor solubility and/or epithelial permeability, thus representing the bulk of drugs under current development by formulation scientists. ![]()
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